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Independent Publications

human-cell-design-publications-endoc-bh5
human-cell-design-publications-endoc-bh3
human-cell-design-publications-ecn90

How other scientists use EndoC-βH5® cells

Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells. Frørup C, Gerwig R, Svane CAS, Mendes Lopes de Melo J, Henriksen K, Fløyel T, Pociot F, Kaur S, Størling J.cFront Endocrinol (Lausanne). 2023 Apr 11;14:1128523. doi: 10.3389/fendo.2023.1128523. eCollection 2023.PMID: 37113489 Free PMC article.
DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes. Brawerman G, Pipella J, Thompson PJ. Mol Metab. 2022 Aug;62:101524. doi: 10.1016/j.molmet.2022.101524. Epub 2022 Jun 2.PMID: 35660116 Free PMC article.
Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion. Szczerbinska I, Tessitore A, Hansson LK, Agrawal A, Ragel Lopez A, Helenius M, Malinowski AR, Gilboa B, Ruby MA, Gupta R, Ämmälä C. Biomedicines. 2022 Jan 4;10(1):103. doi: 10.3390/biomedicines10010103.PMID: 35052782 Free PMC article.
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How other scientists use EndoC-βH1® cells

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates. Tsonkova VG, Sand FW, Wolf XA, Grunnet LG, Kirstine Ringgaard A, Ingvorsen C, Winkel L, Kalisz M, Dalgaard K, Bruun C, Fels JJ, Helgstrand C, Hastrup S, Öberg FK, Vernet E, Sandrini MPB, Shaw AC, Jessen C, Grønborg M, Hald J, Willenbrock H, Madsen D, Wernersson R, Hansson L, Jensen JN, Plesner A, Alanentalo T, Petersen MBK, Grapin-Botton A, Honoré C, Ahnfelt-Rønne J, Hecksher-Sørensen J, Ravassard P, Madsen OD, Rescan C, Frogne T.
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function. Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL.Wellcome Open Res. 2020 Apr 29;4:150. doi: 10.12688/wellcomeopenres.15447.2. eCollection 2019.
Inhibition of the type 1 diabetes candidate gene PTPN2 aggravates TNF-α-induced human beta cell dysfunction and death. Roca-Rivada A, Marín-Cañas S, Colli ML, Vinci C, Sawatani T, Marselli L, Cnop M, Marchetti P, Eizirik DL.Diabetologia. 2023 Aug;66(8):1544-1556. doi: 10.1007/s00125-023-05908-5. Epub 2023 Mar 29.
Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes. Coomans de Brachène A, Castela A, Op de Beeck A, Mirmira RG, Marselli L, Marchetti P, Masse C, Miao W, Leit S, Evans-Molina C, Eizirik DL.Diabetes Obes Metab. 2020 Oct;22(10):1827-1836. doi: 10.1111/dom.14104. Epub 2020 Jul 5.
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How other scientists use EndoC-βH3® cells

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes. Coomans de Brachène A, Castela A, Op de Beeck A, Mirmira RG, Marselli L, Marchetti P, Masse C, Miao W, Leit S, Evans-Molina C, Eizirik DL.Diabetes Obes Metab. 2020 Oct;22(10):1827-1836. doi: 10.1111/dom.14104. Epub 2020 Jul 5.
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How other scientists use ECN90® cells

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept. Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, D’Alessio DA, Haupt A. Mol Metab. 2018 Dec;18:3-14. doi: 10.1016/j.molmet.2018.09.009. Epub 2018 Oct 3.
Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets. Rachdi L, Maugein A, Pechberty S, Armanet M, Hamroune J, Ravassard P, Marullo S, Albagli O, Scharfmann R. Sci Rep. 2020 Aug 10;10(1):13469. doi: 10.1038/s41598-020-69758-6.
Tryptophan metabolism promotes immune evasion in human pancreatic β cells. Rachdi L, Zhou Z, Berthault C, Lourenço C, Fouque A, Domet T, Armanet M, You S, Peakman M, Mallone R, Scharfmann R.EBioMedicine. 2023 Sep;95:104740. doi: 10.1016/j.ebiom.2023.104740. Epub 2023 Aug 1.PMID: 37536063 Free PMC article.
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