HLA-A2 EndoC-βH5®
Human Autoimmune Type 1 Diabetes in a Dish
HLA-A2
EndoC-βH5®
Human Autoimmune Type 1 Diabetes in a Dish
REVOLUTIONIZING AUTOIMMUNE TYPE 1 DIABETES DRUG DISCOVERY
Recapitulate beta cell specific attack after T-cell activation and unlock your innovations with a highly pathologically relevant human Type I Diabetes model
T-cell-mediated autoimmunity leading to beta cell death is a key factor in the progression of Type I diabetes. HLA-A2 EndoC-βH5® is a unique human cell model that robustly recapitulates the pathophysiology of T-cell mediated autoimmunity related to Human Type 1 diabetes. The histocompatibility antigen HLA-A*02 is a critical marker present on pancreatic beta cells of a large number of type 1 diabetic patients. HLA-A2 EndoC-βH5® is a cellular model expressing HLA-A*02 that can replicate in vitro the recognition and destruction of beta cells by CD8+ cytotoxic T cells. HLA-A2 Endoc-BH5® offers a unique solution to combine T-cell killing attack with measuring the indirect impact on insulin secretion and function loss.
FEATURES AND BENEFITS
A Pathophysiological Cell Model Recapitulating Autoimmune Human Beta Cell Attack
HLA-A2-Endoc-BH5® cells enable more accurate clinical predictions by modelling the function decrease and beta cell death in response to T-cell attack observed in Human Type 1 Diabetes
A Patho-physiological Cell Model Recapitulating Autoimmune Human Beta Cell Attack
HLA-A2-Endoc-BH5® cells enable more accurate clinical predictions by modelling the function decrease and beta cell death in response to T-cell attack observed in Human Type 1 Diabetes
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QUALITY ASSURANCE
Validated HLA-A*02 expression
Functional validation (glucose and incretin stimulated insulin secretion)
Negative for mycoplasma
APPLICATIONS
READOUT
CELL MODEL RELEVANCE
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Human Cell Design team of experts can offer you tailored assays and HLA-A2 EndoC-βH5® derived cell models.
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