ENDOC-βH® CELLS
Pharmaceutical R&D and Fundamental Diabetes Research
ENDOC-βH® CELLS
Pharmaceutical R&D and Fundamental Diabetes Research
WHY HUMAN IS CRITICAL?
For decades, scientists had to rely on rodent cell lines to study the mechanisms of insulin secretion and the origin of beta cell dysfunction and destruction observed in human diabetes. This despite major differences in insulin secretion and glucose homeostasis related to species-specific gene expression programs as well as sensitivity to inflammation or autoimmunity.
Rodent beta cells
Human beta cells
Proliferate in vivo
WHY HUMAN CELL DESIGN?
How do EndoC-βH® cells outperform other solutions
Human Cell Design EndoC-BH® cells are the only human pancreatic beta cell models that are able to provide uncompromising functionality, clinical predictability, reproducibility and compatibility with high-throughput screening.
Human Pancreatic Islets | 3D-Spheroid Human Islets | hES / hiPs Derived Beta Cells | EndoC-BH cell lines by Human Cell Design |
|
---|---|---|---|---|
Biological relevance | ● High | ● High | ● High | ● High |
Clinical predictability capacity | ● High | ● High | ● Low | ● High |
Cell model standardization | ● Low | ● High | ● Medium | ● High |
Data reproducibility | ● Low | ● High | ● Medium | ● High |
Time consuming | ● Yes | ● No | ● No | ● No |
HTS compatibility | ● No | ● No | ● Yes | ● Yes |
DISCOVER OUR UNIQUE PANEL OF HUMAN PANCREATIC BETA MODELS
Human Cell Design offers a complete range of human pancreatic beta cell models. From immortalized cell lines to terminally differentiated and highly functional cells, we offer the right cell for your study.
Native Human Beta Cells | EndoC-BH1 | EndoC-BH3 | EndoC-BH5 | |
---|---|---|---|---|
Immortalized cell line | No | Yes | Conditional | No |
Ready to use | No | No | No | Yes |
Insulin content | 100% | 10% | Before excision: 2% After excision: 20% | 100% |
Glucose responsiveness | +++ | + / - | + / - | +++ |
Exendin-4 / GIP responsiveness | +++ | - | - | +++ |
GSIS assay window | 7-10 days | Unlimited | 7-10 days | > 21 days |
HTS compatible | No | Yes | Yes | Yes |
Data resolution | +++ | - | - | +++ |
Data variability | Donor-dependent | Stability over 100 passages | Stability over 85 passages | Stability over batches |
Large batch availability | No | Yes | Yes | Yes |