ENDOC-βH® CELLS

Pharmaceutical R&D and Fundamental Diabetes Research

ENDOC-βH® CELLS

Pharmaceutical R&D and Fundamental Diabetes Research

HUMAN PANCREATIC BETA CELLS

EndoC-βH5®

The ultimate native human beta cell model

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HLA-A2 EndoC-βH5®

The ultimate human autoimmune T1D model

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GLTx EndoC-βH5®

The ultimate human glucolipotoxic T2D model

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EndoC-βH1®

The human beta cell line of reference

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EndoC-βH3®

Conditionally immortalized human beta cells

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ECN-90®

Immortalized autoimmune human beta cells

WHY HUMAN IS CRITICAL?

For decades, scientists had to rely on rodent cell lines to study the mechanisms of insulin secretion and the origin of beta cell dysfunction and destruction observed in human diabetes. This despite major differences in insulin secretion and glucose homeostasis related to species-specific gene expression programs as well as sensitivity to inflammation or autoimmunity.

Rodent beta cells

Rat

Human beta cells

Human

Proliferate in vivo

No natural diabetes
2 genes for insulin
GLUT2 is the main glucose transporter
Do not proliferate in vivo
Type I and Type II diabetes
1 gene for insulin
GLUT1 is the main glucose transporter

WHY HUMAN CELL DESIGN?

How do EndoC-βH® cells outperform other solutions

Human Cell Design EndoC-BH® cells are the only human pancreatic beta cell models that are able to provide uncompromising functionality, clinical predictability, reproducibility and compatibility with high-throughput screening.

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DISCOVER OUR UNIQUE PANEL OF HUMAN PANCREATIC BETA MODELS

Human Cell Design offers a complete range of human pancreatic beta cell models. From immortalized cell lines to terminally differentiated and highly functional cells, we offer the right cell for your study.

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