A human beta cell with conditional immortalisation
ONE STEP CLOSER TO NATIVE HUMAN BETA CELLS
EndoC-βH3® human pancreatic beta cell line is an intermediate version of EndoC-βH® cells. EndoC-βH3® cells are conditionally immortalized and de-immortalization leads to an increase in insulin content and secretion. EndoC-βH3® cells thus represent a translational tool to study beta cell proliferation and apoptosis.
FUNCTIONALLY AND CONDITIONNALY IMMORTALIZED HUMAN BETA CELL
EndoC-βH3® is a conditional excisable high-quality functional human beta cell line
ALREADY TESTED AND APPROVED BY MORE THAN
Academic & pharmaceutical laboratories worldwide
Deposited cell line (Pasteur Institute CNCM)
Short Tandem Repeat analysis available
Batch Release Certificates available
Every batch negatively tested for mycoplasma
Every batch validated for thawing / amplification / GSIS
Insulin content of de-immortalized EndoC-βH3® cells is 10-20 % that of native human beta cells (~1-2 μg/million cells).
Glucose stimulated insulin secretion (GSIS)
De-immortalized EndoC-βH3® cells secrete insulin upon glucose stimulation; secretion is further potentiated by IBMX.