Cytokine-Mediated
Inflammation
KEY ADVANTAGES
Recapitulates physiological beta cell inflammation
IFNγ
RESPONSE
CHRONIC-TREATMENT COMPATIBLE
DATA
REPRODUCIBILITY
Inflammation plays a key role in the pathogenesis of both type 1 and type 2 diabetes, contributing to impaired insulin secretion and progressive beta cell loss.
The Endoc-βH5®-based inflammation assay models the cytokine-induced beta cell stress response, providing you with a robust assay to evaluate anti-inflammatory compounds and beta cell protective mechanisms.
APPLICATIONS
A unique humanized and pharmacologically validated assay
Recapitulates the cytokine-mediated inflammation process of type 1 and type 2 diabetes in vitro
Pathophysiologically-relevant assay
Recapitulates all stages from early inflammation-induced cell dysfunction to apoptosis
Compound screening & profiling
Beta cell loss & dysfunction
ER stress induction
Chronic treatment compatible (>4 weeks)
ASSAY CONCEPT
RESULTS
Anti-inflammatory compound protection
Beta cell loss & dysfunction induced by inflammation can be reversed by anti-inflammatory compounds in EndoC-βH5®
Recover 40% of cell viability with Baricitinib
Restore 75% of lost function with Baricitinib
HAVE A PROJECT IN MIND?
Human Cell Design team of experts can offer you tailored assays and EndoC-βH5® derived cell models.
