EndoC-βH5®
Five versions to become fully similar to native human pancreatic beta cells
KEY ADVANTAGES
No compromise between native islet physiology & cell line reproductibility
ENDOGENEOUS GLP-1/GIP/GCG-R EXPRESSION
PHARMACOLOGICAL VALIDATION
GSIS & CAMP
FUNCTION
DATA CONTINUITY & REPRODUCIBILITY
READY-TO-USE
A ready-to-use pure population of mature functional human beta cells
EndoC-βH5® cells are a major improvement over other models as they are highly similar to native human pancreatic beta cells. They show robust, human beta islets-like levels of insulin secretion in response to glucose and strong GLP-1/GIP receptor activity, making them ideal for studying beta cell physiology, function & apoptosis in diabetes and obesity.
WHY EndoC-βH5® IS UNIQUE?
Overcome false-positive & negative hits with an endogenous and physiologic model
Physiological GLP-1R, GIPR and GCGR surface expression
Robust GLP-1 receptor internalization: β-Arrestin recruitment signal
Sensitive cAMP assay: Screening campaign & mechanistic studies
Pharmacologically-validated insulin secretion: Functional correlation with the receptor activation
PHYSIOLOGICAL & FUNCTIONAL VALIDATION
Dose-Response Glucose Stimulated Insulin secretion (GSIS)
Physiological-relevant model
High sensitivity: up to 10 fold-increase of insulin secretion
Maximum response between 5.5 and 11mM Glucose
Pharmacological-relevant model
High compounds sensitivity: 4-fold-increase of insulin secretion
Physiological response to GLP-1/GIP analogs
Dose-response of GLP-1R and GIPR agonists based on potentiation of GSIS (11mM of glucose)
ALREADY TESTED AND APPROVED BY MORE THAN
Academic & pharmaceutical laboratories worldwide
NEED TO GO ONE STEP FURTHER?
Our Human Cell Design team of experts develops assays and provides you with tailored EndoC-βH5® cell models.
