BETA CELL ENGINEERING PLATFORM
When impossible become possible
KEY ADVANTAGES
Create exclusive models based on genetically modified human native-like beta cells
CRISPR-COMPATIBLE
KO/KI
ROBUSTNESS
LARGE QUANTITY
The ADAPT® platform enables stable gene modification of beta cells, offering a unique tool to validate your target gene in a native-like human model. These fully customized, genetically modified EndoC-βH5® cells are specifically designed for diabetes modeling and screening campaigns.
APPLICATIONS
Knock-in
Transgenesis / Stable transgene overexpression
Knock-down
Lentiviral shRNA
Knock-out
Crispr-KO
Gene expression
Reporter gene
WHY ADAPT®?
A key strategy for designing genome edited human beta cell lines
ADAPT®’s TRACK RECORD
Type 1 and Type 2 Diabetes Modeling
Two functional models have been successfully created through this platform: HLA-A2 EndoC-βH5® and GLTx EndoC-βH5®. From these two pathophysiological models, associated assays have been developed to reveal drug potential: T-cell killing assay and Glucolipotoxicity-mediated Type 2 Diabetes Assay.
WHY CHOOSE HUMAN CELL DESIGN AS YOUR EXPERT PARTNER?
Contact us to discuss your project requirements and challenges and get your project started today!
DISCUSS YOUR NEEDS WITH OUR EXPERTS
– Solutions oriented to support your success
DESIGN YOUR PROJECT
Experimental plan tailored to your objectives
OPTIMIZE YOUR BUDGET, MINIMIZE YOUR RISKS
A step-by-step approach with GO / No GO
EXPLOIT YOUR RESULTS
Full data analysis, comprehensive report, and actionable insights
TRANSPARENCY
Real-time reporting & assigned project manager
